A cikin 'yan shekarun nan,NMN, wanda ya zama sananne a duk faɗin duniya, ya shagaltar da bincike mai zafi da yawa. Nawa kuka sani game da NMN? A yau, za mu mayar da hankali kan gabatar da NMN, wanda kowa ke so.
● MeneneNMN?
Ana kiran NMN β-Nicotinamide Mononucleotide, ko NMN a takaice. NMN yana da diastereomers guda biyu: α da β. Nazarin ya gano cewa kawai nau'in β-nau'in NMN yana da ayyukan nazarin halittu. A tsari, kwayoyin sun ƙunshi nicotinamide, ribose, da phosphate.
NMN yana ɗaya daga cikin abubuwan da suka riga sun kasance na NAD+. A wasu kalmomi, ana samun ainihin tasirin NMN ta hanyar canzawa zuwa NAD +. Yayin da muke tsufa, matakin NAD+ a cikin jikin mutum yana raguwa a hankali.
A cikin Rukunin Binciken Biology na Tsufa na 2018, an taƙaita mahimman hanyoyi guda biyu na tsufa na ɗan adam:
1. Damage lalacewa ta hanyar oxidative stress (alamomi bayyana a matsayin daban-daban cututtuka).
2. Rage matakan NAD + a cikin sel
Yawancin nasarorin ilimi a cikin binciken NAD + anti-tsufa da manyan masana kimiyya na duniya suka goyi bayan ƙaddamar da cewa haɓaka matakan NAD + na iya haɓaka ingancin lafiya a fannoni da yawa da jinkirta tsufa.
● Menene Amfanin LafiyaNMN?
1.Ƙara abun ciki na NAD+
NAD + abu ne mai mahimmanci don kiyaye aikin jiki. Yana wanzuwa a cikin dukkan sel kuma yana shiga cikin dubban halayen physiological a cikin jiki. Fiye da enzymes 500 a cikin jikin mutum suna buƙatar NAD +.
Daga cikin adadi, za mu iya ganin cewa fa'idodin haɓaka NAD+ zuwa gabobin jiki daban-daban sun haɗa da inganta lafiyar kwakwalwa da tsarin juyayi, hanta da koda, tasoshin jini, zuciya, nama na lymphatic, gabobin haihuwa, pancreas, adipose tissue, da tsokoki.
A cikin 2013, ƙungiyar bincike karkashin jagorancin Farfesa David Sinclair na Makarantar Kiwon Lafiya ta Harvard ta tabbatar da gwaje-gwajen cewa bayan gudanar da baki na NMN na tsawon mako guda, matakin NAD + a cikin berayen watanni 22 ya karu, kuma mahimman alamun biochemical masu alaƙa da mitochondrial homeostasis An dawo da aikin tsoka zuwa yanayin ƙananan beraye daidai da watanni 6.
2. Kunna sunadaran SIR
Bincike a cikin shekaru 20 da suka gabata ya gano cewa Sirtuins yana taka muhimmiyar rawa wajen daidaitawa a kusan dukkanin ayyukan tantanin halitta, yana shafar tsarin ilimin lissafi kamar kumburi, haɓakar kwayar halitta, hawan circadian, metabolism makamashi, aikin neuronal da juriya na damuwa.
Sau da yawa ana kiran Sirtuins a matsayin dangin furotin na tsawon rai, wanda shine dangin NAD +-dogaran sunadaran deacetylase.
A cikin 2019, Farfesa Kane AE na Sashen Nazarin Halitta a Makarantar Kiwon Lafiya ta Harvard da sauransu sun gano hakanNMNmuhimmin mafari ne don haɗin NAD + a cikin jiki. Bayan NMN yana haɓaka matakin NAD + a cikin sel, yawancin tasirinsa masu amfani (kamar inganta metabolism, kare tsarin zuciya, da sauransu) ana samun su ta hanyar kunna Sirtuins.
3. Gyara lalacewar DNA
Bugu da ƙari ga rinjayar ayyukan Sirtuins, matakin NAD + a cikin jiki kuma yana da mahimmanci don gyaran DNA na gyaran enzyme PARPs (poly ADP-ribose polymerase).
4. Inganta metabolism
Metabolism tarin halayen sinadaran da ke kula da rayuwa a cikin kwayoyin halitta, yana ba su damar girma da haifuwa, kula da tsarin su, da amsa ga muhalli. Metabolism wani tsari ne wanda kwayoyin halitta ke ci gaba da musayar abubuwa da makamashi. Da zarar ya tsaya, rayuwar kwayoyin halitta za ta ƙare. Farfesa Anthony na Jami'ar California da tawagarsa sun gano cewa NAD + metabolism ya zama magani mai mahimmanci don inganta cututtuka masu alaka da tsufa da kuma tsawaita lafiyar ɗan adam da tsawon rayuwa.
5. Haɓaka farfadowa na jini da kuma kula da elasticity na jini
Tasoshin jini sune mahimman kyallen takarda don jigilar iskar oxygen da abinci mai gina jiki, sarrafa carbon dioxide da metabolites, da daidaita yanayin zafin jiki. Yayin da muke tsufa, jijiyoyin jini a hankali suna rasa sassaucin su, suna zama da wuya, kauri, da kunkuntar, suna haifar da "arteriosclerosis."
A shekarar 2020, wani bincike da wasu daliban jami'ar fasaha ta Zhejiang da ke kasar Sin suka gudanar, ciki har da Sh, ya gano cewa, bayan gudanar da baki.NMNga ɓacin rai, alamun baƙin ciki sun ragu ta hanyar haɓaka matakan NAD +, kunna Sirtuin 3, da haɓaka haɓakar kuzarin mitochondrial a cikin hippocampus da ƙwayoyin hanta na kwakwalwar mice.
6. Kare lafiyar zuciya
Zuciya ita ce mafi mahimmancin gabbai a cikin jikin mutum kuma tana da mahimmanci don kiyaye aikin zuciya. Ragewar matakan NAD + yana da alaƙa da cututtukan cututtukan cututtukan zuciya daban-daban. Yawancin karatu na asali kuma sun nuna cewa ƙarin coenzyme na iya amfana da samfuran cututtukan zuciya.
7. Kula da lafiyar kwakwalwa
Tashin hankali na jijiyoyin jini na iya haifar da farkon jijiyoyin jini da lalacewar fahimi neurodegenerative. Kula da aikin jijiyoyin jini yana da mahimmanci don hana cututtukan neurodegenerative.
Abubuwan haɗari irin su ciwon sukari, hauhawar jini na tsakiya, kiba na tsaka-tsaki, rashin motsa jiki da shan taba duk suna da alaƙa da lalatawar jijiyoyin jini da cutar Alzheimer.
8. Inganta hankalin insulin
Insulin hankali yana bayyana matakin juriya na insulin. Ƙarƙashin hankalin insulin, raguwar matakin raguwar sukari.
Juriya na insulin yana nufin raguwar hankalin gabobin da aka yi niyya na insulin zuwa aikin insulin, wato, yanayin da adadin insulin na yau da kullun ke haifar da ƙasa da tasirin ilimin halitta. Babban abin da ke haifar da nau'in ciwon sukari na 2 shine ƙarancin samar da insulin da ƙarancin kulawar insulin.
NMN, azaman kari, na iya taimakawa inganta haɓakar insulin ta hanyar haɓaka matakan NAD +, daidaita hanyoyin rayuwa, da haɓaka aikin mitochondrial.
9. Taimakawa tare da sarrafa nauyi
Nauyi ba wai kawai yana rinjayar ingancin rayuwa da lafiya ba, amma har ma ya zama abin jawo ga wasu cututtuka na yau da kullum. Nazarin ya nuna cewa NAD precursor β-nicotinamide mononucleotide (NMN) na iya juyar da wasu mummunan tasirin abinci mai kitse (HFD).
A cikin 2017, Farfesa David Sinclair na Makarantar Kiwon Lafiya ta Harvard da ƙungiyar bincike daga Makarantar Kiwon Lafiya ta Australiya sun kwatanta berayen mata masu kiba waɗanda suka yi motsa jiki a kan injin tuƙi har tsawon makonni 9 ko kuma an yi musu allurar NMN kowace rana har tsawon kwanaki 18. Sakamakon ya nuna cewa NMN ya zama kamar yana da tasiri mai karfi akan ƙwayar hanta mai hanta da haɗuwa fiye da motsa jiki.
●Lafiya naNMN
Ana ɗaukar NMN lafiya a cikin gwaje-gwajen dabba, kuma sakamakon yana ƙarfafawa. An fara gwajin gwaji na asibiti 19 na ɗan adam, wanda 2 daga cikinsu sun buga sakamakon gwaji.
Wata ƙungiyar bincike daga Makarantar Magunguna ta Jami'ar Washington a St. Louis ta buga wata kasida a cikin babbar mujallar kimiyya ta "Kimiyya", ta bayyana sakamakon gwajin gwaji na farko na ɗan adam a duniya, wanda ke tabbatar da fa'idodin rayuwa na NMN a jikin ɗan adam.
●NEWGREEN Samar da NMN Foda/Capsules/Liposomal NMN
Lokacin aikawa: Oktoba-15-2024
